Most Amrita Vidyalayams follow the CBSE curriculum, with 34 schools affiliated, including 27 senior secondary schools. The Kollam, Kerala, branch follows ICSE. All CBSE schools use Continuous and Comprehensive Evaluation (CCE) and emphasize a stress-free environment with co-curricular activities. The schools boast a 100% pass rate in Board exams, and M.A. Math supports talented, economically disadvantaged students.

At Amrita Vidyalayam, the senior secondary school curriculum is designed to provide an in-depth and specialized education that prepares students for higher studies and professional careers. Core subjects include advanced mathematics, physics, chemistry, biology, computer science, commerce, and more. The curriculum emphasizes critical thinking, analytical skills, and practical applications. Value-based education, focusing on empathy, respect, and ethical conduct, is integral to the curriculum. Co-curricular activities, including physical education, arts, and various clubs, ensure well-rounded development, equipping students for future academic and personal success.